Schmitz, Gerd and Liebisch, Gerhard and Langmann, Thomas (2006) Lipidomic strategies to study structural and functional defects of ABC-transporters in cellular lipid trafficking. FEBS LETTERS, 580 (23). pp. 5597-5610. ISSN 0014-5793
Full text not available from this repository. (Request a copy)Abstract
The majority of the human ATP-binding cassette (ABC)-transporters function in cellular lipid trafficking and in the regulation of membrane lipid composition associating their dysfunction with human disease phenotypes related to sterol, phospholipid and fatty acid homeostasis. Based on findings from monogenetic disorders, animal models, and in vitro systems, major clues on the expression, function and cellular localization of human ABC-transporters have been gained. Here we review novel lipidomic technologies including quantitative mRNA expression monitoring by realtime RT-PCR and DNA-microarrays, lipid mass spectrometry, cellular fluorescence imaging and flow cytometry as promising tools to further define regulatory networks, lipid species patterns and subcellular domains important for ABC-transporter-mediated lipid trafficking. (c) 2006 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TANDEM MASS-SPECTROMETRY; HIGH-DENSITY-LIPOPROTEIN; HISTOCOMPATIBILITY ANTIGEN HA-1; HIGH-THROUGHPUT QUANTIFICATION; BINDING CASSETTE TRANSPORTERS; FAMILIAL INTRAHEPATIC CHOLESTASIS; REVERSE CHOLESTEROL TRANSPORT; CORONARY-ARTERY DISEASE; UNSATURATED FATTY-ACIDS; APOLIPOPROTEIN-A-I; lipidomics; ABC-transporters; lipid trafficking disorders |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Feb 2021 11:35 |
| Last Modified: | 24 Feb 2021 11:35 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33885 |
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