Driemel, O. and Kraft, K. and Hemmer, Joerg (2006) Flow cytometric S-phase fraction contributes to diagnosis of diploid malignant salivary gland tumours. INTERNATIONAL JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, 35 (10). pp. 947-950. ISSN 0901-5027,
Full text not available from this repository. (Request a copy)Abstract
DNA ploidy studies on salivary gland tumours have shown that the proportion of aneuploid cases, although confined to the malignant entities, is considerably lower than for other solid malignancies. To analyse whether the S-phase fraction (SPF) may contribute to discrimination of diploid malignant from benign tumours, DNA flow cytometric data from 45 different malignant salivary gland tumours was compared with that of 121 pleomorphic adenomas. All benign tumours were diploid. Twelve malignant tumours contained aneuploid cell populations. The SPF values for diploid malignancies ranged between 0.9% and 11.0% (mean 3.9%), and between 0.5% and 7.9% (mean 2.7%) for pleomorphic adenomas. A 4% cut-off value gained statistical significance for discriminating diploid malignant tumours from pleomorphic adenomas (P < 0.01). The sensitivity for SPF > 4% was 46% and the positive predictive value was 40%. A sensitivity of 60% and a positive predictive value of 54% was achieved by combining aneuploidy and SPF > 4%. These results show that DNA flow cytometry may contribute to diagnostic assessment in salivary gland tumours.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ADENOID CYSTIC CARCINOMA; PLEOMORPHIC ADENOMA; CELL-CARCINOMA; DNA ANALYSIS; ANEUPLOIDY; PLOIDY; salivary gland tumours; DNA flow cytometry; aneuploidy; S-phase fraction |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Mund-, Kiefer- und Gesichtschirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jan 2021 09:14 |
| Last Modified: | 25 Jan 2021 09:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33942 |
Actions (login required)
 |
View Item |
