Brinkmann, R. and Schuele, G. and Neumann, J. and Framme, C. and Poerksen, E. and Elsner, H. and Theisen-Kunde, D. and Roider, J. and Birngruber, R. (2006) Selective retina therapy. Methods, technique, and online dosimetry. OPHTHALMOLOGE, 103 (10). pp. 839-849. ISSN 0941-293X,
Full text not available from this repository. (Request a copy)Abstract
Selective retina therapy (SRT) is currently under evaluation, as a new and very subtle laser method, for the treatment of retinal disorders associated with a degradation of the retinal pigmentary epithelium (RPE). SRT makes it possible to selevtively effect the RPE, sparing the adjacent neural retina with the photoreceptors and also the choroid below the RPE. In the best case, the therapy leads to regeneration of the RPE and a long-term metabolic increase at the chorio-retinal junction. In contrast to conventional laser photocoagulation, which is associated with complete thermal necrosis of and around the treated site, absolutely no scotoma occurs in SRT. This paper reviews the methods and mechanisms behind the selective effects of the RPE. In vitro and preclinical results are used to describe the bandwidth of selective effects with respect to different irradiation settings. An optoacoustic technique is introduced to visualize effects that cannot be seen by ophthalmoscopy and to facilitate dosimetry control without recourse to angiography completes the report.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PIGMENT EPITHELIUM; LASER-PULSES; BRUCHS MEMBRANE; TIME REGIMEN; PHOTOCOAGULATION; DAMAGE; RPE; PHOTOTHERMOLYSIS; THRESHOLDS; EXPOSURE; selective cell effects; optoacoustic technique; microbubbles; online dosimetry; macular edema |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Augenheilkunde |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 25 Jan 2021 10:13 |
| Last Modified: | 25 Jan 2021 10:13 |
| URI: | https://pred.uni-regensburg.de/id/eprint/33980 |
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