Puellmann, Kerstin and Kaminski, Wolfgang E. and Vogel, Mandy and Nebe, C. Thomas and Schroeder, Josef and Wolf, Hans and Beham, Alexander W. (2006) A variable immunoreceptor in a subpopulation of human neutrophils. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 103 (39). pp. 14441-14446. ISSN 0027-8424,
Full text not available from this repository. (Request a copy)Abstract
Neutrophils are thought to rely solely on nonspecific immune mechanisms. Here we provide molecular biological, immunological, ultrastructural, and functional evidence for the presence of a T cell receptor (TCR)-based variable immunoreceptor in a 5-8% subpopulation of human neutrophils. We demonstrate that these peripheral blood neutrophils express variable and individual-specific TCR alpha beta repertoires and the RAG1/RAG2 recombinase complex. The proinflammatory cytokine granulocyte colony-stimulating factor regulates expression of the neutrophil immunoreceptor and RAG1/RAG2 in vivo. Specific engagement of the neutrophil TCR complex protects from apoptosis and stimulates secretion of the neutrophil-activating chemokine IL-8. Our results, which also demonstrate the presence of the TCR in murine neutrophils, suggest the coexistence of a variable and an innate host defense system in mammalian neutrophils.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | T-CELL-RECEPTOR; SEVERE COMBINED IMMUNODEFICIENCY; MYELOID DIFFERENTIATION PROGRAM; PROTEOMIC ANALYSIS; TYROSINE KINASE; ZETA-CHAIN; EXPRESSION; DIVERSITY; MUTATION; ZAP-70; innate immune system; neutrophil granulocyte; T cell receptor |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 27 Jan 2021 10:31 |
| Last Modified: | 27 Jan 2021 10:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34011 |
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