Shafer, Orie Thomas and Helfrich-Foerster, Charlotte and Renn, Susan Christine Portia and Taghert, Paul H. (2006) Reevaluation of Drosophila melanogaster's neuronal circadian pacemakers reveals new neuronal classes. JOURNAL OF COMPARATIVE NEUROLOGY, 498 (2). pp. 180-193. ISSN 0021-9967,
Full text not available from this repository. (Request a copy)Abstract
In the brain of the fly Drosophila melanogaster, similar to 150 clock-neurons are organized to synchronize and maintain behavioral rhythms, but the physiological and neurochemical bases of their interactions are largely unknown. Here we reevaluate the cellular properties of these pacemakers by application of a novel genetic reporter and several phenotypic markers. First, we describe an enhancer trap marker called R32 that specifically reveals several previously undescribed aspects of the fly's central neuronal pacemakers. We find evidence for a previously unappreciated class of neuronal pacemakers, the lateral posterior neurons (LPNs), and establish anatomical, molecular, and developmental criteria to establish a subclass within the dorsal neuron 1 (DN1) group of pacemakers. Furthermore, we show that the neuropeptide IPNamide is specifically expressed by this DN1 subclass. These observations implicate IPNamide as a second candidate circadian transmitter in the Drosophila brain. Finally, we present molecular and anatomical evidence for unrecognized phenotypic diversity within each of four established classes of clock neurons.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BEHAVIORAL RHYTHMS; NERVOUS-SYSTEM; GENE ENCODES; CLOCK GENES; BRAIN; PERIOD; PROTEIN; NEUROPEPTIDE; EXPRESSION; CELLS; Drosophila; circadian clock; neuropeptides; PDF receptor; IPNamide; nplp1; glass |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Alumni or Retired > Organisation der inneren Uhr auf neuronaler Ebene (Prof. Dr. Charlotte Förster) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2021 08:07 |
| Last Modified: | 01 Feb 2021 08:07 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34034 |
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