Kramm, Christof M. and Wagner, Sabine and Van Gool, Stefan and Schmid, Hansjoerg and Straeter, Ronald and Gnekow, Astrid and Rutkowski, Stefan and Wolff, Johannes E. A. (2006) Improved survival after gross total resection of malignant gliomas in pediatric patients from the HIT-GBM studies. ANTICANCER RESEARCH, 26 (5B). pp. 3773-3779. ISSN 0250-7005,
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The present study was performed to investigate the prognostic impact of tumor resection on survival in children and adolescents with malignant gliomas. From the HIT-GBM data base of the Gesellschaft fur Paediatrische Onkologie und Haematologie (GPOH), 85 pediatric patients with malignant non-pontine gliomas were analyzed. Histological diagnosis and extent of tumor resection had been confirmed by central neuropathological review and post-surgical imaging. The extent of tumor resection represented the most prominent prognostic factor for overall (OS) and event-free survival (EFS) in univariate and Cox regression analyses. Four-year survival after gross total tumor resection was 48.0 +/- 12.0% (OS) and 14.1 +/- 8.9% (EFS), after non-total resection 13.2 +/- 6.1% and 2.9 +/- 2.8%, respectively. From several clinical parameters, only histological grading displayed a similar statistical significance in Cox regression analysis. In conclusion, gross total tumor resection improves survival in pediatric patients with malignant gliomas and should always be attempted when possible.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HIGH-GRADE GLIOMA; GLIOBLASTOMA-MULTIFORME; SURGICAL RESECTION; RANDOMIZED-TRIAL; CHILDREN; EXTENT; CHILDHOOD; PROGNOSIS; ASTROCYTOMAS; CHEMOTHERAPY; neurosurgery; tumor resection; glioblastoma; anaplastic astrocytoma; malignant glioma; survival |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Pädiatrische Hämatologie, Onkologie und Stammzelltransplantation |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2021 10:22 |
| Last Modified: | 01 Feb 2021 10:22 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34047 |
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