Li, Xiaoqiang and Miltschitzky, Stefan and Koenig, Burkhard (2006) Luminescent pyrimidine hydrazide oligomers with peptide affinity. BIOORGANIC & MEDICINAL CHEMISTRY, 14 (17). pp. 6075-6084. ISSN 0968-0896,
Full text not available from this repository. (Request a copy)Abstract
The modular synthesis of pyrimidine oligohydrazides and their peptide binding ability are reported. Ethylene glycol substituents ensure water solubility of the compounds. The pattern of hydrogen bond donors and hydrogen bond acceptors resembles the functionalities of a peptide backbone, and intramolecular hydrogen bonds restrict conformational mobility. The pyrimidine heterocycles show emission at 423 nm if either excited with light of 320 nm or by a FRET process from a nearby Trp residue. This property is useful for the luminescent detection of interactions with peptides and proteins. (c) 2006 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ARTIFICIAL BETA-SHEET; AMINO-ACIDS MOPAS; GROWTH-HORMONE; CONCANAVALIN-A; MODEL SYSTEMS; RECOGNITION; FOLDAMERS; LIGANDS; DESIGN; STRAND; peptide mimics; pyrimidine; hydrazine acid; luminescence; FRET |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Lehrstuhl Prof. Dr. Burkhard König |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2021 10:29 |
| Last Modified: | 01 Feb 2021 10:29 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34052 |
Actions (login required)
 |
View Item |
