Holtmann, Martin H. and Krummenauer, Frank and Claas, Christina and Kremeyer, Kristina and Lorenz, Dirk and Rainer, Olivia and Vogel, Iris and Boecker, Ulrich and Boehm, Stephan and Buening, Carsten and Duchmann, Rainer and Gerken, Guido and Herfarth, Hans and Luegering, Norbert and Kruis, Wolfgang and Reinshagen, Max and Schmidt, Jan and Stallmach, Andreas and Stein, Juergen and Sturm, Andreas and Galle, Peter R. and Hommes, Daan W. and D'Haens, Geert and Rutgeerts, Paul and Neurath, Markus F. (2006) Long-term effectiveness of azathioprine in IBD beyond 4 years: A European multicenter study in 1176 patients. DIGESTIVE DISEASES AND SCIENCES, 51 (9). pp. 1516-1524. ISSN 0163-2116,
Full text not available from this repository. (Request a copy)Abstract
In Crohn's disease the optimal duration of azathioprine treatment is still controversial and for ulcerative colitis only limited data are available to support its efficacy. Charts of 1176 patients with IBD from 16 European centers were analyzed. Flare incidences and steroid dosages were assessed for the time before and during treatment and after discontinuation. Within the first 4 years, azathioprine suppressed flare incidence and steroid consumption in both diseases (P < 0.001). While in CD discontinuation after 3-4 years did not lead to reactivation, this was the case in UC. However, continuation beyond 4 years further improved clinical activity in CD and steroid requirement in both diseases (P < 0.001). Discontinuation of azathioprine may thus be considered after 3-4 years in CD patients in complete remission without steroid requirement. In all other CD patients and for UC patients in general, continuation seems beneficial. These results support a novel differential algorithm for long-term azathioprine therapy in IBD.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CHRONIC ULCERATIVE-COLITIS; CONTROLLED TRIAL; CROHNS-DISEASE; 6-MERCAPTOPURINE; MANAGEMENT; azathioprine; Crohn's disease; ulcerative colitis; long-term immunosuppression |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 01 Feb 2021 10:59 |
| Last Modified: | 01 Feb 2021 10:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34069 |
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