Pfeiler, G. H. and Lattrich, C. and Schambeck, C. and Langmann, T. and Treeck, O. and Ortmann, O. (2006) Metabolismus und Mammakarzinom = Breast cancer and metabolism. GEBURTSHILFE UND FRAUENHEILKUNDE, 66 (9). pp. 841-851. ISSN 0016-5751, 1438-8804
Full text not available from this repository. (Request a copy)Abstract
Metabolic disorders are known to affect the risk for breast cancer. Obesity affects the risk and prognosis of different kinds of cancers, including breast cancer. Metabolic changes, such as increased estrogen biosynthesis, elevated serum free fatty acids (FFA), or hyperinsulinemia, associated with the metabolic syndrome are considered to be responsible for the effects of obesity on breast cancer. Furthermore, white adipose tissue secretes a wide range of biologically active peptides, including adiponectin, leptin, TNF alpha and IL-6. These adipocytokines have been shown to be involved in the development and progression of breast cancer. The focus of this review is to summarize the current knowledge on metabolic disorders as risk factors for breast cancer.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-I; NECROSIS-FACTOR-ALPHA; IGF-BINDING-PROTEINS; BODY-MASS INDEX; MAMMARY EPITHELIAL-CELLS; INSULIN-RECEPTOR CONTENT; HORMONE REPLACEMENT THERAPY; CYCLIN E-CDK2 ACTIVATION; POSTMENOPAUSAL WOMEN; PROSPECTIVE COHORT; breast cancer; lipid metabolism; type 2 diabetes mellitus; adipocytokines; obesity |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Frauenheilkunde) Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Feb 2021 07:34 |
| Last Modified: | 24 Feb 2021 07:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34082 |
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