Voigt, R. and Axt-Fliedner, R. and Frank, V. and Eckhold, J. and Zuther, C. and Germer, Ute and Gernbruch, U. and Diedrich, K. and Schwinger, E. (2006) Changes in invasive prenatal diagnostics. GEBURTSHILFE UND FRAUENHEILKUNDE, 66 (9). pp. 870-875. ISSN 0016-5751,
Full text not available from this repository. (Request a copy)Abstract
The indications for invasive prenatal diagnosis (PND) for the detection of fetal chromosomal abnormalities have shifted during the last decade. The exclusive indication for invasive diagnostics because of maternal age (age of the pregnant women >= 35 years) has, become less important in favor of an individual indication consisting of maternal age, detailed ultrasonography and fetal echocardiography. Using high resolution ultrasound scan and vaginal ultrasound fetal anomalies or markers (for example structural anomalies such as omphalocele, heart defects, CNS abnormalities, megacystis and anomalies of the extremities, and "markers" such as enlarged nuchal translucency, hygroma colli and hydrops fetalis) associated with chromosomal abnormalities and non chromosomal severe syndromes can be detected during the first trimester. The early detection of such structural anomalies and markers for syndromes makes it possible to offer invasive diagnostics for fetal karyotyping after detailed and individual counseling of the couples. The development of non-invasive methods in prenatal diagnostics are reflected in a decline of invasive prenatal interventions (amniocentesis [AC], chorionic villi sampling [CVS]) with an increase of abnormal chromosomal findings during the last 15 years at the department of gynecology and the institute of human genetics of the university of Luebeck.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | FETAL NUCHAL TRANSLUCENCY; LOW-RISK PREGNANCIES; CHROMOSOMAL DEFECTS; FIRST-TRIMESTER; WEEKS GESTATION; NASAL BONE; TRISOMY-21; THICKNESS; FETUSES; ABSENCE; prenatal diagnosis; amniocentesis; chorionic villi sampling; chromosomal aberrations |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Frauenheilkunde und Geburtshilfe (Schwerpunkt Geburtshilfe) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 02 Feb 2021 12:48 |
| Last Modified: | 02 Feb 2021 12:49 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34084 |
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