Seliger, Corinna and Meier, Christoph Rudolf and Becker, Claudia and Jick, Susan Sara and Bogdahn, Ulrich and Hau, Peter and Leitzmann, Michael Fred (2016) Statin use and risk of glioma: population-based case-control analysis. EUROPEAN JOURNAL OF EPIDEMIOLOGY, 31 (9). pp. 947-952. ISSN 0393-2990, 1573-7284
Full text not available from this repository. (Request a copy)Abstract
Statins have been reported to decrease the incidence of cancer, but the risk of glioma among statin users has been investigated in only two prior observational studies, both of them suggesting a modest protective effect of statins. We conducted a matched case-control study using data from the UK-based Clinical Practice Research Datalink to analyse use of statins among 2469 cases with glioma and 24,690 controls. We performed conditional logistic regression analysis to calculate relative risks, estimated as odds ratios (ORs) with 95 % confidence intervals (CIs) adjusting for multiple confounding factors. As compared with non-use of statins, use of statins was not associated with risk of glioma (OR for aeyen90 prescriptions=0.75; 95 % CI 0.48-1.17). Our findings do not support previous sparse evidence of a possible inverse association between statin use and glioma risk.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HUMAN GLIOBLASTOMA CELLS; INDUCED APOPTOSIS; INHIBITION; LOVASTATIN; PROLIFERATION; MIGRATION; KINASE; Glioma; Epidemiology; Case-control study; Statins |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Institut für Epidemiologie und Präventivmedizin > Lehrstuhl für Genetische Epidemiologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Apr 2019 13:00 |
| Last Modified: | 04 Apr 2019 13:00 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3412 |
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