Ibach, Bernd and Binder, Harald and Dragon, Margarethe and PoIjansky, Stefan and Haen, Ekkehard and Schmitz, Eberhard and Koch, Horst and Putzhammer, Albert and Kluenemann, Hans and Wieland, Wolf and Hajak, Goeran (2006) Cerebrospinal fluid tau and beta-amyloid in Alzheimer patients, disease controls and an age-matched random sample. NEUROBIOLOGY OF AGING, 27 (9). pp. 1202-1211. ISSN 0197-4580, 1558-1497
Full text not available from this repository. (Request a copy)Abstract
We prospectively evaluated the diagnostic accuracy of cerebrospinal fluid (CSF)-beta-antyloid(1-42) (A beta(42)), -total-tau (tau) and -phosphorylated-tau(181) (p-tau,81) as measured by sandwich ELISAs in the clinical routine of a community state hospital to discriminate between patients with Alzheimer's disease (AD), healthy controls (HQ, non-AD-dementias,a group composed of various psychiatric disorders (non-AD-dementias, mental diseases) and an age-matched random sample (RS) (total N = 219). By comparing patients with AD to HC as reference, tau revealed sensitivity (sens)/specificity (spec) of 88%/80%, p-tau(181) 88%/80%, tau/A beta(42)-ratio 81%/85% and phospho-tau(181)/A beta(42)-ratio 81%/78%. Discriminative power between HC and all dementias under investigation was estimated lower for tau (78%/77%) and p-tau(181) (73%/79%). Relative to patients with AD, ROC analysis for the RS revealed highest sens/spec for p-tau(181) (79%/77%) and p-tau(181)/A beta(42) ratio (78%/75%). Differentiation between AD versus a group made of patients with various psychiatric disorders was optimised by using CSF-p-tau(181) (80%/77%). Under clinical routine conditions current CSF-biomarkers show a substantial capacity to discriminate between AD and HC as reference and to mark off AD patients from RS and heterogeneous diagnostic groups composed of non-AD dementias and other psychiatric conditions. Despite a residual substantial overlap between the groups, we conclude that current CSF markers are well suited to support AD-related diagnostic procedures in every-day clinics. (c) 2005 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CSF-TAU; FRONTOTEMPORAL DEGENERATION; CLINICAL-DIAGNOSIS; LARGE-SCALE; DEMENTIA; PROTEIN; MULTICENTER; A-BETA-1-42(43); IMMUNOGLOBULIN; CONSORTIUM; Alzheimer's disease; non-Alzheimer dementias; dementia; psychiatric disorders; depression; schizophrenia; cerebrospinal fluid; tau; phosphorylated tau; beta-amyloid(42); random sample |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Lehrstuhl für Urologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Feb 2021 07:47 |
| Last Modified: | 03 Feb 2021 07:47 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34131 |
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