Windschiegl, Barbara and Steinem, Claudia (2006) Influence of alpha-hydroxylation of glycolipidson domain formation in lipid monolayers. LANGMUIR, 22 (18). pp. 7454-7457. ISSN 0743-7463,
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By means of fluorescence and scanning force microscopy (SFM), we investigated the phase behavior of lipid monolayers composed of a mixture of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine, sphingomyelin, and cholesterol (5/2/3) with either alpha-hydroxylated or nonhydroxylated galactocerebroside. Fluorescence images of lipid monolayers at the air-water interface demonstrate that, independent of the lipid mixture, phase separation occurs at low surface pressure up to 4-6 mN m(-1), while an almost homogeneous phase is observed at larger surface pressures. However, by means of SFM of lipid monolayers transferred by the Langmuir-Blodgett technique at around 30 mN m(-1), nanometer-sized domains became discernible in those lipid mixtures that contained galactocerebroside, while, in that without a glycolipid, no such domain formation was visible. Moreover, the alpha-hydroxy group of the galactocerebroside alters the size and the total area of the domains significantly.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ATOMIC-FORCE MICROSCOPY; DETERGENT-RESISTANT MEMBRANES; CONDENSED COMPLEXES; MODEL MEMBRANES; GANGLIOSIDE GM1; RAFT FORMATION; CHOLESTEROL; BILAYERS; PHOSPHATIDYLCHOLINE; CEREBROSIDES; |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Analytische Chemie, Chemo- und Biosensorik > Bioanalytik und Biosensorik (Prof. Joachim Wegener) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 03 Feb 2021 10:45 |
| Last Modified: | 03 Feb 2021 10:45 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34155 |
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