Mueller, Rainer and Abke, Jochen and Schnell, Edith and Scharnweber, Dieter and Kujat, Richard and Englert, Carsten and Taheri, Darius and Nerlich, Michael and Angele, Peter (2006) Influence of surface pretreatment of titanium- and cobalt-based biomaterials on covalent immobilization of fibrillar collagen. BIOMATERIALS, 27 (22). pp. 4059-4068. ISSN 0142-9612, 1878-5905
Full text not available from this repository. (Request a copy)Abstract
Collagen type-I is a major component of the extracellular matrix Of Most tissues and it is increasingly utilized for surface engineering of biomaterials to accelerate receptor-mediated cell adhesion. In the present study, coatings with layers of fibrillar type-I collagen were prepared on titanium, titanium alloy, and cobalt alloy to improve initial osteoblast adhesion and implant-tissue integration. To suppress the quick in vivo degradation rate of collagen the deposited layers were covalently immobilized at the metal surfaces as well as chemically cross-linked. The application of different oxidation techniques to the metallic substrates resulted in surfaces with varying hydroxyl group contents, which directly influenced the amount of immobilized silane coupling agents. It was found that a high density of surface-bound coupling agents increased the stability of the covalently linked collagen layers. After coating of metallic biomaterials with a cross-linked collagen layer, an improved cellular response of human osteoblast-like cells (MG-63) in vitro could be recognized. (c) 2006 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MESENCHYMAL STEM-CELLS; CO-CR-MO; AMINO-GROUPS; I COLLAGEN; ADHESION; DIFFERENTIATION; OSTEOBLASTS; ATTACHMENT; ALLOY; BIOCOMPATIBILITY; surface modification; titanium alloys; cobalt alloys; collagen; coupling agents; cross-linking |
| Subjects: | 500 Science > 540 Chemistry & allied sciences 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Unfallchirurgie Chemistry and Pharmacy > Institut für Physikalische und Theoretische Chemie > Chair of Chemistry VI - Physical Chemistry (Solution Chemistry) > PD Dr. Rainer Müller |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 08 Feb 2021 09:19 |
| Last Modified: | 08 Feb 2021 09:19 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34186 |
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