Schumann, Christian and Triantafilou, Kathy and Rasche, F. Maximilian and Moericke, Angelika and Vogt, Konstanze and Triantafilou, Martha and Hahn, Philipp and Schneider, E. Marion and Lepper, Philipp M. (2006) Serum antibody positivity for distinct Helicobacter pylori antigens in benign and malignant gastroduodenal disease. INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY, 296 (4-5). pp. 223-228. ISSN 1438-4221
Full text not available from this repository. (Request a copy)Abstract
Infection with Helicobacter pylori may be associated with a variety of gastroduodenal diseases. Although H. pylori infection is common, peptic ulcer disease and gastric cancer Occur in only a small minority of infected persons. This work was intended to correlate the pathological findings with the serological response to certain H. pylori antigens. Serum samples were taken from 285 patients who underwent gastroscopy. H. pylori infection was diagnosed by histology, culture or rapid urease test (RUT). Serum IgG reactivity against H. pylori-specific antigens was studied by Western blot. There was a significant association between the diagnosis of gastric cancer and the presence of IgG antibodies against the 19.5, 33 and 136 kDa (CagA) antigens. Comparing all H. pylori-positive patients with the gastric cancer group for the presence of the 19.5, 33 and 136 kDa (CagA) antigens, the results were as follows: chi(2) : 17.482, p < 0.001, power P = 0.994, odds ratio (OR) for the presence of gastric cancer: 19.5 (95% confidence interval (CI): 4.11-92.56). Antibodies against CagA alone or other bands (except 33 and 19.5 kDa antigens), as well as the age of patients were not related to a diagnosis of gastric cancer. Male patients were more likely to develop duodenal ulcer. IgG antibodies against the 19.5, 33 and 136 kDa (CagA) antigens could be helpful to identify patients at enhanced risk for the development of gastric cancer. (c) 2006 Elsevier GmbH. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GASTRIC-CANCER; INCREASED RISK; NONULCER DYSPEPSIA; VIRULENCE FACTORS; INFECTION; CAGA; CARCINOMA; ADENOCARCINOMA; SEROPOSITIVITY; ULCER; Helicobacter pylori; gastric cancer; serology; 33-kDa antigen; Western blotting |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Feb 2021 06:26 |
| Last Modified: | 24 Feb 2021 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34230 |
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