Sutmuller, Roger P. M. and Morgan, Mary E. and Netea, Mihai G. and Grauer, Oliver and Adema, Gosse J. (2006) Toll-like receptors on regulatory T cells: expanding immune regulation. TRENDS IN IMMUNOLOGY, 27 (8). pp. 387-393. ISSN 1471-4906
Full text not available from this repository. (Request a copy)Abstract
Regulatory T (Treg) cells maintain peripheral tolerance and limit effector responses to prevent excessive immune-mediated tissue damage. However, recent research reveals that Treg cells also dampen the induction of immune responses and, thus, must be controlled to enable the effective protection against infections and cancer. Until now, this control of Treg-cell function has been believed to be by communication through cytokines or by stimulation through co-stimulatory molecules on antigen-presenting cells. However, new evidence has demonstrated that Treg cells can also sense pathogens directly through Toll-like receptors (TLRs) and, consequently, modify their behaviour. This review examines the ramifications of TLR engagement on Treg cells and conventional T cells, and discusses the potential role of TLRs on Treg cells and the consequences for disease therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IMMUNOLOGICAL SELF-TOLERANCE; GROWTH-FACTOR-BETA; ACTIVATED PROTEIN-KINASE; INDUCED TNF RECEPTOR; DENDRITIC CELLS; CUTTING EDGE; TGF-BETA; MEDIATED SUPPRESSION; AUTOIMMUNE-DISEASE; EFFECTOR FUNCTION; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 24 Feb 2021 06:06 |
| Last Modified: | 24 Feb 2021 06:06 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34277 |
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