Schoretsanitis, Georgios and Stegmann, Benedikt and Hiemke, Christoph and Gruender, Gerhard and Schruers, Koen R. J. and Walther, Sebastian and Lammertz, Sarah E. and Haen, Ekkehard and Paulzen, Michael (2016) Pharmacokinetic patterns of risperidone-associated adverse drug reactions. EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY, 72 (9). pp. 1091-1098. ISSN 0031-6970, 1432-1041
Full text not available from this repository. (Request a copy)Abstract
The aim of the study was to investigate a correlation between plasma concentrations of risperidone (RIS), its active metabolite 9-hydroxyrisperidone (9-OH-RIS) and the active moiety (AM) (RIS + 9-OH-RIS), and adverse drug reactions (ADRs) in a naturalistic sample. Plasma concentrations of RIS, 9-OH-RIS, and AM in patients out of a therapeutic drug monitoring (TDM) database complaining ADRs were categorized according to the Udvalg for Kliniske Undersogelser side effect rating scales (UKU) (n = 97) and compared to patients without ADRs (n = 398). Patients in the ADR group received a significantly lower daily dosage of risperidone (trimmed mean 3.64 mg/day) than patients without ADRs (4.40 mg/day). No differences were found for active moiety plasma concentrations between the groups (p = 0.454). Differences were detected only in the case of dose-adjusted plasma concentration values (concentration-by-dose, C/D) for 9-OH-RIS, being higher in patients reporting ADRs (4.78 ng/mL/mg) than in patients without ADRs (4.3 ng/mL/mg) (p = 0.037 for Mann-Whitney U test). Note that differences for non-adjusted 9-OH-RIS plasma levels between groups failed to reach significance (p = 0.697). Our findings are consistent with previous data supporting a prominent role of 9-hydroxyrisperidone, but not of risperidone with regard to ADRs. When studying the various subgroups of reported ADRs separately, the size of these subsamples offers some plausible limitations by reducing the power of the analysis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SCHIZOPHRENIC-PATIENTS; CLINICAL-RESPONSE; 1ST-EPISODE SCHIZOPHRENIA; EXTRAPYRAMIDAL SYMPTOMS; ANTIPSYCHOTIC TREATMENT; NEUROLEPTIC MEDICATION; PLASMA-CONCENTRATIONS; 9-HYDROXY METABOLITE; CYTOCHROME-P450 2D6; PROLACTIN LEVELS; Antipsychotics; Drug metabolism; Psychopharmacology; Schizophrenia; Pharmacokinetics |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Psychiatrie und Psychotherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 04 Apr 2019 13:30 |
| Last Modified: | 04 Apr 2019 13:30 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3430 |
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