Bosserhoff, Anja-Katrin (2006) Integrins as targets in therapy. EXPERT OPINION ON THERAPEUTIC PATENTS, 16 (7). pp. 963-975. ISSN 1354-3776
Full text not available from this repository. (Request a copy)Abstract
Cell adhesion and migration are essential for embryonic development, tissue regeneration and homeostasis. Deregulation results in several kinds of diseases, for example, in tumour development. The physical link between the extracellular matrix (ECM) and the actin cytoskeleton is mainly mediated by receptors of the integrin family. This family of proteins plays key roles in cellular processes through signals transduced upon integrin ligation to ECM proteins. During disease development, changes in integrin expression, intracellular control of integrin functions and signals perceived from integrin ligand-binding impact upon the ability of cells to interact with their environment. Antagonists of several integrins are now under evaluation in clinical trials to determine their potential as therapeutics for several kinds of diseases including cancer. Newly characterised and patented inhibitors of integrins are summarised in this review.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | cardiovascular diseases; cell attachment; cell migration; inflammatory disease; integrin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Petra Gürster |
| Date Deposited: | 23 Feb 2021 09:48 |
| Last Modified: | 23 Feb 2021 09:48 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34345 |
Actions (login required)
 |
View Item |
