Fraunberger, P and Wang, Y and Holler, E and Parhofer, KG and Nagel, D and Walli, AK and Seidel, D (2006) Prognostic value of interleukin 6, procalcitonin, and C-reactive protein levels in intensive care unit patients during first increase of fever. SHOCK, 26 (1). pp. 10-12. ISSN 1073-2322,
Full text not available from this repository. (Request a copy)Abstract
To investigate the prognostic value of interleukin 6 (IL-6), procalcitonin (PCT), and C-reactive protein (CRP) in critically ill patients during the first increase of fever, serum levels were measured in 38 patients admitted to intensive care unit of the Department of Medicine, Klinikum Grobhadern, University of Munich, immediately after increase of body temperature above 38.3 degrees C. Ten healthy controls were also included for comparison. The onset of fever was accompanied by elevated circulating levels of all the 3 markers in comparison with healthy controls. However, only IL-6 levels were significantly higher (P < 0.05) in nonsurvivors (n = 21) compared with survivors. Sensitivity, specificity, positive, and negative predictive values calculated from median levels was higher for IL-6 compared with PCT and CRP. Areas under receiver characteristic operating curves revealed the highest area under the curve for IL-6 in contrast to PCT and CRP. These data suggest that IL-6 rather than PCT or CRP may be an early predictor of mortality in patients with onset of fever and identify patients, who need intensive monitoring to initiate appropriate therapy at an early stage.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BACTERIAL-INFECTION; ORGAN FAILURE; SEPSIS; GUIDELINES; CIRRHOSIS; INCREASE; MARKER; SHOCK; cytokines; procalcitonin; fever; infection; sepsis; prognosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Feb 2021 10:23 |
| Last Modified: | 11 Feb 2021 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34417 |
Actions (login required)
 |
View Item |
