Kleiter, I. and Steinbrecher, A. and Fluegel, D. and Bogdahn, U. and Schulte-Mattler, W. (2006) Autonomic involvement in tick-borne encephalitis (TBE): Report of five cases. EUROPEAN JOURNAL OF MEDICAL RESEARCH, 11 (6). pp. 261-265. ISSN 0949-2321, 2047-783X
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Background: Tick-borne encephalitis (TBE) is a viral infection of the CNS with significant acute and long-term morbidity. Dysfunction of the autonomic nervous system may be a potentially harmful complication of TBE. Material and Methods: In a retrospective case series, 5 patients with acute TBE were evaluated for clinical signs of autonomic dysfunction and subject to autonomic testing. Heart rate variability (HRV) with 6 per minute deep breathing was performed between day 9 to 31 after onset of meningitis. Follow-up data were available in three cases. Results: All patients showed clinical signs of autonomic dysfunction, including upper and lower gastrointestinal tract symptoms, orthostatic hypotension, and urinary retention. A reduced HRV was observed in 4 patients, with sustained sinus tachycardia in 2 of them. The minimum of the HRV was reached 9 to 20 days after onset of meningitis. In one patient, normalization of the HRV occurred within 3 months. Conclusion: Acute TBE can be associated with autonomic dysfunction including reduced HRV and tachycardia. Prospective studies are needed to analyze the incidence of autonomic dysfunction in TBE, and to clarify which patients have the highest risk for autonomic failure.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NEUROPATHY; DISEASE; VIRUS; BRAIN; STAGE; tick-borne encephalitis; autonomic nervous system; dysautonomia; heart rate variability; tachycardia |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Feb 2021 12:21 |
| Last Modified: | 11 Feb 2021 12:21 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34422 |
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