Valis, Linda and Mayer-Enthart, Elke and Wagenknecht, Hans-Achim (2006) 8-(pyren-1-yl)-2'-deoxyguanosine as an optical probe for DNA hybridization and for charge transfer with small peptides. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 16 (12). pp. 3184-3187. ISSN 0960-894X, 1464-3405
Full text not available from this repository. (Request a copy)Abstract
8-(Pyren-1-yl)-2-deoxyguanosine (Py-G) was incorporated synthetically as an optical probe into oligonucleotides. The Py-G group in DNA does not discriminate between any of the four natural nucleosides as a counterbase and exhibits altered optical properties in single strands versus double strands. Thus, the duplex hybridization of Py-G-modified DNA can be observed by both fluorescence and absorption spectroscopy. Moreover, Py-G in DNA can be applied as photoinducable donor for charge transfer processes with small peptides. (c) 2006 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | REDUCTIVE ELECTRON-TRANSFER; PYRIMIDINE NUCLEOSIDES; MOLECULAR BEACONS; AQUEOUS-SOLUTION; ENERGY-TRANSFER; NUCLEIC-ACIDS; BASE; PYRENE; RADICALS; DYNAMICS; charge transfer; DNA; fluorescence; oligonucleotide; peptide; pyrene |
| Subjects: | 500 Science > 540 Chemistry & allied sciences |
| Divisions: | Chemistry and Pharmacy > Institut für Organische Chemie > Alumni or Retired Professors > Arbeitskreis Prof. Dr. Hans-Achim Wagenknecht |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Feb 2021 12:40 |
| Last Modified: | 11 Feb 2021 12:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34441 |
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