Audebert, Franz and Schneidewind, Arne and Hartmann, Pia and Kullmann, Frank and Schoelmerich, Juergen (2006) Lymph node tuberculosis as primary manifestation of Hodgkin's disease. MEDIZINISCHE KLINIK, 101 (6). pp. 500-504. ISSN 0723-5003,
Full text not available from this repository. (Request a copy)Abstract
History and Findings on Admission: A 63-year-old female patient was admitted to the authors' hospital for further diagnostic work-up for suspected reactivation of a previously successfully treated lymph node tuberculosis, which had been diagnosed 1 year prior to the current admission. The clinical signs consisted of worsening of the patient's general condition, cervical lymphadenopathy, night sweats, dyspnea, and superficial inflammation of the right mamma. Findings: A contrast-enhanced CT scan of the neck, thorax and abdomen revealed a generalized enlargement of the cervical, axillar, mediastinal and retroperitoneal lymph nodes, multiple intrapulmonary nodular lesions with a diameter of up to 6 mm, and a substantial right-sided pleural effusion. Course of Disease: Under the assumption of reactivation of a lymph node tuberculosis, the patient was initially treated with an extended tuberculostatic therapy. Because of disease progression another lymph node biopsy was performed revealing Hodgkin's disease of mixed-cellularity type with a partly histiocytic necrotizing, partly tuberculoid reaction. The biopsy was negative for acid-fast bacilli. Thereupon initiated chemotherapy according to the ABVD protocol led to a rapid amelioration of the clinical symptoms. Conclusion: In the clinical setting of suspected or confirmed lymph node tuberculosis malignant lymphoma should always be considered. This consideration is particular important since Hodgkin's disease is typically associated with a cellular immunosuppression predisposing the subject to tuberculosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TUMOR-NECROSIS-FACTOR; MYCOBACTERIUM-TUBERCULOSIS; MONOCLONAL-ANTIBODY; DOUBLE-BLIND; T-CELLS; IMMUNOLOGY; INFECTION; IMMUNITY; CD8(+); LUNGS; tuberculosis; TB; Hodgkin's disease; MDR-TB; multiple-drug resistance; lymphogranulomatosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 11 Feb 2021 12:50 |
| Last Modified: | 11 Feb 2021 12:50 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34444 |
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