Kleinjung, Tobias and Steffens, T. and Langguth, B. and Eichhammer, R. and Marienhagen, J. and Hajak, Goeran and Strutz, J. (2006) Treatment of chronic tinnitus with neuronavigated repetitive Transcranial Magnetic Stimulation (rTMS). HNO, 54 (6). pp. 439-444. ISSN 0017-6192,
Full text not available from this repository. (Request a copy)Abstract
Background and objective. Idiopathic tinnitus is a frequent and debilitating disorder of largely unknown pathophysiology. Focal brain activation in the auditory cortex has recently been demonstrated in chronic tinnitus. Low-frequency rTMS can reduce cortical hyperexcitability. Patients and methods. In 12 patients with chronic tinnitus, fusion of [F-18]deoxyglucose-PET and structural MRI (T1, MPRAGE) scans allowed the area of increased metabolic activity in the auditory cortex to be exactly identified; this area was selected as the target for rTMS. A neuronavigational system adapted for TMS positioning enabled the relative positions of the figure-8 coil and the target area to be monitored. Repetitive TMS (110% motor threshold; 1 Hz; 2000 stimuli per day over 5 days) was performed using a placebo-controlled crossover design. A sham coil system was used for the placebo stimulation. Treatment outcome was assessed with a specific tinnitus questionnaire (Goebel and Hiller). Results. In all 12 patients an asymmetrically increased metabolic activation of the gyrus of Heschl was detected. The tinnitus score was significantly improved after 5 days of active rTMS, an effect not seen after placebo stimulation. Conclusion. These preliminary results show that neuronavigated rTMS may improve our understanding and treatment of chronic tinnitus.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MOTOR CORTEX EXCITABILITY; AUDITORY-CORTEX; RETRAINING THERAPY; PLASTICITY; MECHANISMS; BRAIN; tinnitus; transcranial magnetic stimulation; neuroplasticity; positron emission tomography; neuronavigation |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Hals-Nasen-Ohren-Heilkunde Medicine > Lehrstuhl für Psychiatrie und Psychotherapie Medicine > Abteilung für Nuklearmedizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 07:55 |
| Last Modified: | 15 Feb 2021 07:55 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34489 |
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