Zoicas, Iulia and Menon, Rohit and Neumann, Inga D. (2016) Neuropeptide S reduces fear and avoidance of con-specifics induced by social fear conditioning and social defeat, respectively. NEUROPHARMACOLOGY, 108. pp. 284-291. ISSN 0028-3908, 1873-7064
Full text not available from this repository. (Request a copy)Abstract
Neuropeptide S (NPS) has anxiolytic effects and facilitates extinction of cued fear in rodents. Here, we investigated whether NPS reverses social fear and social avoidance induced by social fear conditioning (SFC) and acute social defeat (SD), respectively, in male CD1 mice. Our results revealed that intra-cerebroventricular NPS (icy; 10 and 50 nmol/2 mu l) reversed fear of unknown con-specifics induced by SFC and dose-dependently reduced avoidance of known aggressive con-specifics induced by SD. While 50 nmol of NPS completely reversed social avoidance and reinstated social preference, 10 nmol of NPS reduced social avoidance, but did not completely reinstate social preference in socially-defeated mice. Further, a lower dose (1 nmol/2 mu l) of NPS facilitated the within-session extinction of cued fear, while a higher dose (10 nmol/2 mu l) reduced the expression of cued fear. We could also confirm the anxiolytic effects of NPS (1,10 and 50 nmol/2 mu l) on the elevated plus-maze (EPM), which were not accompanied by alterations in locomotor activity either on the EPM or in the home cage. Finally, we could show that icy infusion of the NPS receptor 1 antagonist D-Cys(Bu-t)(5)-NPS (10 nmol/2 mu l) did not alter SFC-induced social fear, general anxiety and locomotor activity. Taken together, our study extends the potent anxiolytic profile of NPS to a social context by demonstrating the reduction of social fear and social avoidance, thus providing the framework for studies investigating the involvement of the NPS system in the regulation of different types of social behaviour. (C) 2016 Elsevier Ltd. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPOTHALAMIC HYPOCRETIN SYSTEM; EXPRESSING NEURONS; GOLDEN-HAMSTERS; MOUSE-BRAIN; RECEPTOR; ANXIETY; MICE; STRESS; EXTINCTION; ACTIVATION; Neuropeptide S; Social fear conditioning; Cued fear conditioning; Social defeat; Social avoidance; Anxiety |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Tierphysiologie/Neurobiologie (Prof. Dr. Inga Neumann) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 05 Apr 2019 08:43 |
| Last Modified: | 05 Apr 2019 08:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3449 |
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