Xu, Ruian and Harrison, Phillip M. and Chen, Miao and Li, Linyan and Tsui, Tung-yu and Fung, Peter C. W. and Cheung, Pik-to and Wang, Guangji and Li, Hua and Diao, Yong and Krissansen, Geoffrey W. and Xu, Sue and Farzaneh, Farzin (2006) Cytoglobin overexpression protects against damage-induced fibrosis. MOLECULAR THERAPY, 13 (6). pp. 1093-1100. ISSN 1525-0016,
Full text not available from this repository. (Request a copy)Abstract
Cytoglobin (Cygb), a member of the hexacoordinate globin superfamily (hxHb), is expressed in fibroblasts from a broad range of tissues. The physiological functions of hxHb are still unclear, but biochemical studies reveal that they can scavenge toxic species, such as nitric oxide, peroxynitrite, and hydrogen peroxide. We demonstrate that the overexpression of Cygb in rat hepatic stellate cells, both in vitro and in vivo, protects against oxidative stress, inhibiting their differentiation into a myofibroblast-like phenotype. Accordingly, the overexpression of Cygb reduces extracellular matrix deposition in both toxic and cholestatic models of liver injury. The overexpression of Cygb also promotes recovery from previously initiated damage-induced fibrogenesis. By inhibiting free radical-induced activation of hepatic stellate cells, Cygb plays an important role in controlling tissue fibrosis. Therefore, the normal upregulation of Cygb during tissue injury has a homeostatic effect, inhibiting free radical-induced fibroblast activation and tissue fibrosis.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LIGAND-BINDING; HUMAN NEUROGLOBIN; HEXACOORDINATE HEMOGLOBIN; IN-VIVO; EXPRESSION; BRAIN; MACROPHAGES; DISTINCT; HYPOXIA; TISSUES; cytoglobin; stellate cell activation associated protein; hexacoordinate globin superfamily; hepatic stellate cells; liver damage; fibrosis; cirrhosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 07:17 |
| Last Modified: | 15 Feb 2021 07:17 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34516 |
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