Stadler, Peter and Schafer, Christof and Chaber, Silvia and Putnik, Kurt and Treutwein, Marius and Koelbl, Oliver and Muders, Frank (2006) Clinical results of intracoronary brachytherapy (ICBT) for multiple in-stent restenosis. STRAHLENTHERAPIE UND ONKOLOGIE, 182 (6). pp. 312-317. ISSN 0179-7158,
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Background and Purpose: Treatment of in-stent restenosis (ISR) with percutaneous coronary intervention (PCI) alone is often followed by early re-restenosis. The present study focused on the effect of intracoronary brachytherapy (ICBT) on multiple in-stent restenosis (MISR) after repeated PCI. Patients and Methods: 40 patients (27 mate, 13 female, age: 66 9 years) with MISR (two to six ISRs, median three ISRs) were retrospectively analyzed. ALL patients were treated by using the Novoste (R) Beta-Cath (TM) 3.5F System after PCI. The target vessel received 18.4-25.3 Gy of radiation at a depth of 2 mm from the center of the source. The restenosis-free survival and overall survival were calculated by KapLan-Meier analysis (Log-rank). The time interval between Last PCI without ICBT and the consecutive recurrence was compared with the follow-up time after PCI with ICBT. Results: The 3-year overall survival rate after ICBT was 93%. The 0.5-, 1-, 2-, and 3-year ISR-free survival rates after PCI + ICBT were 81%, 72%, 52%, and 38%, respectivey. After PCI alone, the 0.5-, 1-, and 2-year ISR-free survival rates were 30%, 13%, and 0%, respectively. This difference was highly significant (p < 0.0001). Patients with more than three ISRs before ICBT had a better outcome (3-year ISR-free survival: 80%) than patients with only two or three ISRs before ICBT (3-year ISR-free survival: 25%; p < 0.05). Conclusion: ICBT is highly effective and safe in patients with ISR. The results of this study are in accordance with the WRIST and BETA-WRIST data. After 6 months both studies revealed an ISR-free survival rate of 86% (WRIST) and 66% (BETA-WRIST), respectively. The ISR rates in the own control group (70%) were comparable to the placebo groups in WRIST (68%) and BETA-WRIST (72%). Interestingly, patients with more than three ISRs before ICBT had the Lowest ISR rate after ICBT.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | TRANSLUMINAL CORONARY ANGIOPLASTY; GAMMA-RADIATION THERAPY; ANGIOGRAPHIC FOLLOW-UP; BETA-RADIATION; BALLOON ANGIOPLASTY; TASK-FORCE; HETEROTOPIC OSSIFICATION; WASHINGTON RADIATION; INHIBITS RECURRENCE; LONG WRIST; percutaneous coronary intervention; PCI; percutaneous transluminal coronary angioplasty; PTCA; intracoronary brachytherapy; coronary artery radiation therapy; in-stent restenosis |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Strahlentherapie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 10:02 |
| Last Modified: | 15 Feb 2021 10:02 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34521 |
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