Guse, C. and Koennings, S. and Maschke, A. and Hacker, M. and Becker, C. and Schreiner, S. and Blunk, T. and Spruss, T. and Goepferich, Achim (2006) Biocompatibility and erosion behavior of implants made of triglycerides and blends with cholesterol and phospholipids. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 314 (2). pp. 153-160. ISSN 0378-5173, 1873-3476
Full text not available from this repository. (Request a copy)Abstract
Triglycerides are a promising class of material for the parenteral delivery of drugs and have become the focus of tremendous research efforts in recent years. The aim of this study was to investigate the biocompatibility of glycerol tripalmitate as well as the influence of cholesterol and distearoyl-phosphatidyl-choline (DSPC) on the erosion behavior of the lipid. For these investigations, two in vivo studies were carried out, in which cylindrical matrices of 2 mm diameter were manufactured and subcutaneously implanted in immunocompetent NMRI-mice. After excision of the implants, tissue reactions of the animals as well as changes in the weight, shape and microstructure of the implants were investigated. The triglyceride and cholesterol showed good biocompatibility, as indicated by their minimal encapsulation in connective tissue and the absence of inflammatory reactions. Increasing the levels of phospholipid in the implants, however, led to an increased inflammatory reaction. In contrast to cholesterol, which did not affect erosion, the incorporation of DSPC into the triglyceride matrices led to clearly visible signs of degradation. (c) 2006 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | IN-VITRO; MICROSPHERES; RELEASE; implants; biocompatibility; triglyceride; phospholipid; cholesterol |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 10:23 |
| Last Modified: | 15 Feb 2021 10:23 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34539 |
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