Guse, C. and Koennings, S. and Blunk, T. and Siepmann, J. and Goepferich, A. (2006) Programmable implants - From pulsatile to controlled release. INTERNATIONAL JOURNAL OF PHARMACEUTICS, 314 (2). pp. 161-169. ISSN 0378-5173, 1873-3476
Full text not available from this repository. (Request a copy)Abstract
The aim of this study was to develop programmable implants with a reproducible delayed onset of release followed by several weeks of controlled release. For this purpose, a drug-loaded core was embedded into a drug-free bulk-eroding poly(D,L lactic-co-glycolic acid) or poly(D,L lactic acid) mantle. The manufacturing procedure was established and optimized for three mantle materials, which showed delay times ranging from 7 to 83 days. Triglycerides with fatty acid chain lengths from C-12 to C-18 were investigated as core materials, producing release periods from 2 to 16 weeks. Concomitantly, applying a convolution/deconvolution model showed the possibility of theoretical prediction of the resulting release profiles. (c) 2006 Elsevier B.V. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DRUG-DELIVERY; MICROCHIP; MATRICES; implants; controlled release; pulsatile release; triglyceride; convolution |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical Technology (Prof. Göpferich) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 07:59 |
| Last Modified: | 15 Feb 2021 07:59 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34540 |
Actions (login required)
 |
View Item |
