Kalteis, Thomas and Beckmann, Johannes and Schroeder, Hans-Juergen and Schaumburger, Jens and Linde, Hans-Joerg and Lerch, Klaus and Lehn, Norbert (2006) Treatment of implant-associated infections with moxifloxacin: An animal study. INTERNATIONAL JOURNAL OF ANTIMICROBIAL AGENTS, 27 (5). pp. 444-448. ISSN 0924-8579, 1872-7913
Full text not available from this repository. (Request a copy)Abstract
The efficacy of moxifloxacin in the treatment of an implant-associated infection by Staphylococcus aureus was compared with vancomycin in an animal study. The femoral medullary cavity of 36 Wistar rats was contaminated with S. aureus (ATCC 29213) and a metal device was implanted. After treatment for 14 days with moxifloxacin (2 x 10 mg/kg/day) or vancomycin (2 x 15 mg/kg/day), the bacterial counts (colony-forming units) in the periprosthetic bone, the soft tissue and the implant-associated biofilm were measured. Compared with the control group, moxifloxacin achieved a highly significant decrease in the microbial counts in the bone and soft tissue and in the biofilm (P < 0.001). Moreover, the efficacy of moxifloxacin was significantly greater than that of vancomycin (P < 0.01). Vancomycin did not reduce the microbial count significantly compared with the control group (P > 0.05). The results justify further investigations of the treatment of implant-associated infections due to S. aureus with moxifloxacin. (c) 2006 Elsevier B.V. and the International Society of Chemotherapy. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | STAPHYLOCOCCUS-AUREUS; QUINUPRISTIN-DALFOPRISTIN; LOCAL INFECTION; VANCOMYCIN; OSTEOMYELITIS; PHARMACOKINETICS; FLUOROQUINOLONES; ARTHROPLASTIES; CIPROFLOXACIN; PENETRATION; moxifloxacin; implant-associated infection; prosthetic infection; Staphylococcus aureus |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Orthopädie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 12:10 |
| Last Modified: | 15 Feb 2021 12:10 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34580 |
Actions (login required)
 |
View Item |
