Dietmaier, Wolfgang and Bettstetter, M and Wild, PJ and Woenckhaus, M and Ruemmele, Petra and Hartmann, A and Dechant, S and Blaszyk, H and Pauer, A and Klinkhammer-Schalke, Monika and Hofstaedter, Ferdinand (2006) Nuclear Maspin expression is associated with response to adjuvant 5-fluorouracil based chemotherapy in patients with stage III colon cancer. INTERNATIONAL JOURNAL OF CANCER, 118 (9). pp. 2247-2254. ISSN 0020-7136,
Full text not available from this repository. (Request a copy)Abstract
Maspin, a member of the Serpin protease inhibitor family, is over-expressed in poorly differentiated colorectal tumors and more frequently found in tumors with microsatellite instability. Immunohistochemical nuclear Maspin staining is predominantly seen in tumor cells at the invasion front of such cancers, suggesting that this molecule is associated with local tumor cell infiltration and aggressiveness. In a retrospective study, we studied nuclear Maspin expression as a potential prognostic tool in a total of 172 primary stage III colon cancers by immunohistochemistry. Of those 172 patients, 76 were treated by surgery only, and 96 patients received additional adjuvant 5-fluorouracil (5-FU) based chemotherapy. Nuclear Maspin expression was an independent adverse prognostic factor for overall survival in our patient cohort (hazard ratio 2.08; 95% CI, 1.13-3.81; p = 0.018). However, patients with primary tumors expressing Maspin in the nucleus showed a significant treatment benefit from 5-FU chemotherapy (hazard ratio 0.384; 95% CI, 0.188-0.784; p = 0.009) compared to adjuvantly treated patients whose tumors did not express this molecule. Nuclear Maspin expression is highly predictive of 5-FU chemotherapy response in patients with advanced stage colon cancer. Patients with negative immunhistochemical Maspin expression do not benefit from 5-FU treatment anti may be candidates for an alternative (non-5-FU based) adjuvant therapy regime. (c) 2005 Wiley-Liss, Inc.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SUPPRESSOR GENE MASPIN; THYMIDYLATE SYNTHASE EXPRESSION; ADVANCED COLORECTAL-CANCER; CELL LUNG-CANCER; MICROSATELLITE-INSTABILITY; THYMIDINE PHOSPHORYLASE; SURVIVAL BENEFIT; CARCINOMA; FLUOROURACIL; PREDICTS; colon cancer; Maspin; prediction; 5-flourouracil; chemotherapy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 12:34 |
| Last Modified: | 15 Feb 2021 12:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34581 |
Actions (login required)
 |
View Item |
