Hoffmann, Ute and Segerer, Stephan and Ruemmele, Petra and Krueger, Bernd and Pietrzyk, Miriam and Hofstaedter, Ferdinand and Banas, Bernhard and Kramer, Bernhard K. (2006) Expression of the chemokine receptor CXCR3 in human renal allografts - a prospective study. NEPHROLOGY DIALYSIS TRANSPLANTATION, 21 (5). pp. 1373-1381. ISSN 0931-0509, 1460-2385
Full text not available from this repository. (Request a copy)Abstract
Background. Mechanisms involved in the recruitment and activation of inflammatory cells during renal allograft injury are still incompletely understood. Since chemokines play pivotal roles in this process, our prospective study was performed to evaluate further the role of the chemokine receptor CXCR3. Methods. A total of 138 biopsies were included from patients without rejection and unaltered morphology (according to Banff 97 classification grade 1, n = 49), with acute interstitial rejection (Banff grade 4 type I, n = 8), with acute vascular rejection (Banff grade 4 type II, n = 23), with chronic allograft nephropathy (Banff grade 5, n = 16), without rejection but with various other lesions (Banff grade 6, n = 36) and from pre-transplant kidneys (n = 6). The expression of CXCR3-, CD4- and CD8-positive cells was localized by immunohistochemistry and quantified by image analysis. Results. CXCR3 was expressed by infiltrating inflammatory cells, but not by intrinsic renal structures. CXCR3-positive cells were found to be involved in tubulitis and vascular rejection. The area of CXCR3-positive staining was significantly larger in biopsies with acute interstitial rejection (P < 0.001) and acute vascular rejection (P < 0.001) as compared with normal renal graft biopsies. There was a strong morphological and numerical correlation between CXCR3 and both CD4- and CD8-positive T cells, respectively. Conclusions. A significant part of both CD4- and CD8-positive T cells express the chemokine receptor CXCR3. During renal allograft rejection, the number of these cells increases significantly at the site of injury and might be targeted by CXCR3 blocking agents.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | ACUTE REJECTION; T-CELLS; CXCR3-BINDING CHEMOKINES; INTERNATIONAL UNION; IP-10; INFILTRATION; VASCULOPATHY; NOMENCLATURE; PHARMACOLOGY; NEPHROPATHY; chemokine receptors; CXCR3; human renal allograft rejection; immunohistochemistry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 12:58 |
| Last Modified: | 15 Feb 2021 12:58 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34596 |
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