Castrop, H. and Schiessl, I. M. (2017) Novel routes of albumin passage across the glomerular filtration barrier. ACTA PHYSIOLOGICA, 219 (3). pp. 546-555. ISSN 1748-1708, 1748-1716
Full text not available from this repository. (Request a copy)Abstract
Albuminuria is a hallmark of kidney diseases of various aetiologies and an unambiguous symptom of the compromised integrity of the glomerular filtration barrier. Furthermore, there is increasing evidence that albuminuria per se aggravates the development and progression of chronic kidney disease. This review covers new aspects of the movement of large plasma proteins across the glomerular filtration barrier in health and disease. Specifically, this review focuses on the role of endocytosis and transcytosis of albumin by podocytes, which constitutes a new pathway of plasma proteins across the filtration barrier. Thus, we summarize what is known about the mechanisms of albumin endocytosis by podocytes and address the fate of the endocytosed albumin, which is directed to lysosomal degradation or transcellular movement with subsequent vesicular release into the urinary space. We also address the functional consequences of overt albumin endocytosis by podocytes, such as the formation of pro-inflammatory cytokines, which might eventually result in a deterioration of podocyte function. Finally, we consider the diagnostic potential of podocyte-derived albumin-containing vesicles in the urine as an early marker of a compromised glomerular barrier function. In terms of new technical approaches, the review covers how our knowledge of the movement of albumin across the glomerular filtration barrier has expanded by the use of new intravital imaging techniques.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PROXIMAL TUBULAR CELLS; ENDOPLASMIC-RETICULUM STRESS; EPITHELIAL-CELLS; IN-VIVO; SEGMENTAL GLOMERULOSCLEROSIS; MULTIPHOTON MICROSCOPY; FATTY-ACIDS; MICROPUNCTURE TECHNIQUE; ENDOTHELIAL GLYCOCALYX; DIABETIC-NEPHROPATHY; albuminuria; endocytosis; exosomes; glomerular filtration; multi-photon microscopy; transcytosis |
| Subjects: | 500 Science > 570 Life sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Physiologie > Prof. Dr. Wolf Hayo Castrop |
| Depositing User: | Petra Gürster |
| Date Deposited: | 14 Dec 2018 13:01 |
| Last Modified: | 20 Oct 2020 06:26 |
| URI: | https://pred.uni-regensburg.de/id/eprint/346 |
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