Bauer, R and Humphries, M and Fassler, R and Winklmeier, A and Craig, SE and Bosserhoff, Anja Katrin (2006) Regulation of integrin activity by MIA. JOURNAL OF BIOLOGICAL CHEMISTRY, 281 (17). pp. 11669-11677. ISSN 0021-9258, 1083-351X
Full text not available from this repository. (Request a copy)Abstract
MIA ( melanoma inhibitory activity) has been identified as a small protein secreted from malignant melanoma cells, which interacts with extracellular matrix proteins including fibronectin. Here, we show that MIA negatively regulates the activity of the mitogen-activated protein kinase pathway in malignant melanoma. Using far Western blotting and co-immunoprecipitation we searched for MIA-binding cell surface proteins. We found that MIA interacts with integrin alpha 4 beta 1 and alpha 5 beta 1, leading to down-regulation of integrin activity and reduction of mitogen-activated protein kinase signaling. These findings also suggest that MIA may play a role in tumor progression and the spread of malignant melanomas via mediating detachment of cells from extracellular matrix molecules by modulating integrin activity. Inhibiting MIA functions in vivo may therefore provide a novel therapeutic strategy for metastatic melanoma disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MELANOMA INHIBITORY-ACTIVITY; MALIGNANT-MELANOMA; ALPHA-4 INTEGRIN; ADHESION; PROTEIN; CELLS; METASTASIS; MIGRATION; CLEAVAGE; INVASION; |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 15 Feb 2021 13:52 |
| Last Modified: | 15 Feb 2021 13:52 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34652 |
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