Tzankov, Alexandar and Gschwendtner, Andreas and Augustin, Florian and Fiegl, Michael and Obermann, Ellen C. and Dirnhofer, Stephan and Went, Philip (2006) Diffuse large B-cell lymphoma with overexpression of cyclin E substantiates poor standard treatment response and inferior outcome. CLINICAL CANCER RESEARCH, 12 (7). pp. 2125-2132. ISSN 1078-0432,
Full text not available from this repository. (Request a copy)Abstract
Purpose: Gold standard to predict survival and stratify patients for risk-adapted therapy in diffuse large B-cell lymphoma (DLBCL) is the international prognostic index, although it does not consider the molecular heterogeneity of DLBCL. Deregulation of cyclin E (CCNE) is a strong predictor of poor prognosis in some neoplastic diseases. In tumor cells, it induces chromosomal instability with an increased rate of aneuploidy/polyploidy. Experimental Design: We analyzed in this retrospective study the prognostic value of immunohistochemical CCNE expression on a validated tissue microarray containing 101 de novo DLBCLs and, in 9 cases, the CCNE-induced chromosomal instability as assessed by cytometry. Results: Forty-six of 98 evaluable DLBCLs expressed CCNE in a mean proportion of 20 29% of tumor cells; 38 cases expressed CCNE in >= 20% of tumor cells. CCNE-positive samples were aneuploid compared with near tetraploidy in CCNE-negative cases. Multivariate analysis showed CCNE expression in >= 20% of tumor cells to be an international prognostic index - independent, Adriamycin-based treatment-independent, and BCL2-independent prognostic factor for poor disease-specific survival. CCNE expression in >= 80% of tumor cells was associated with dismal short-term prognosis. CCNE expression in >= 50% of tumor cells emerged as an independent predictive factor for standard CHOP treatment resistance. Conclusions: CCNE expression assessment is easy on paraffin-embedded tissue. The high prognostic value of CCNE expression in DLBCL may be the basis for future prospective trials. In addition, a high CCNE expression hints at the presence of a possible target for individualized cancer therapy.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | NON-HODGKINS-LYMPHOMA; TISSUE MICROARRAY ANALYSIS; DEPENDENT KINASE; MALIGNANT-LYMPHOMAS; TUMOR-CELLS; PROGNOSTIC IMPLICATIONS; INTERFERON-ALPHA; GENE-EXPRESSION; S-PHASE; CANCER; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Feb 2021 07:27 |
| Last Modified: | 17 Feb 2021 07:27 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34728 |
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