Wachs, Frank-Peter and Winner, Beate and Couillard-Despres, Sebastien and Schiller, Thorsten and Aigner, Robert and Winkler, Juergen and Bogdahn, Ulrich and Aigner, Ludwig (2006) Transforming growth factor-beta 1 is a negative modulator of adult neurogenesis. JOURNAL OF NEUROPATHOLOGY AND EXPERIMENTAL NEUROLOGY, 65 (4). pp. 358-370. ISSN 0022-3069, 1554-6578
Full text not available from this repository. (Request a copy)Abstract
Transforming growth factor (TGF)-beta 1 has multiple functions in the adult central nervous system (CNS). It modulates inflammatory responses in the CNS and controls proliferation of microglia and astrocytes. In the diseased brain, TGF-beta 1 expression is upregulated and, depending on the cellular context, its activity can be beneficial or detrimental regarding regeneration. We focus on the role of TGF-beta 1 in adult neural stem cell biology and neurogenesis. In adult neural stem and progenitor cell cultures and after intracerebroventricular infusion, TGF-beta 1 induced a long-lasting inhibition of neural stem and progenitor cell proliferation and a reduction in neurogenesis. In vitro, although TGF-beta 1 specifically arrested neural stem and progenitor cells in the G0/1 phase of the cell cycle, it did not affect the self-renewal capacity and the differentiation fate of these cells. Also, in vivo, TGF-beta 1 did not influence the differentiation fate of newly generated cells as shown by bromo-deoxyuridine incorporation experiments. Based on these data, we suggest that TGF-beta 1 is an important signaling molecule involved in the control of neural stem and progenitor cell proliferation in the CNS. This might have potential implications for neurogenesis in a variety of TGF-beta 1-associated CNS diseases and pathologic conditions.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-BETA; NEURAL STEM-CELLS; HEMATOPOIETIC STEM/PROGENITOR CELLS; MIDDLE CEREBRAL-ARTERY; CENTRAL-NERVOUS-SYSTEM; TGF-BETA; TRANSFORMING GROWTH-FACTOR-BETA-1; ALZHEIMERS-DISEASE; HUNTINGTONS-DISEASE; TRANSGENIC MICE; brain repair; cell fate; differentiation; doublecortin; neurodegenerative diseases |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 17 Feb 2021 09:18 |
| Last Modified: | 17 Feb 2021 09:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34750 |
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