Gray, D and Obermann, EC and Evans, M and Hartmann, Arndt and Cooper, K and Blaszyk, Hagen (2006) MIB-1 and MCM-2 immunohistochemical analysis does not aid in identification of serrated colorectal polyps with abnormal proliferation. AMERICAN JOURNAL OF CLINICAL PATHOLOGY, 125 (3). pp. 407-412. ISSN 0002-9173,
Full text not available from this repository.Abstract
We investigated the staining characteristics of serrated polyps with abnormal proliferation (SPAP) using MIB-1 and MCM-2 to determine if the), could provide assistance in delineating SPAPs from traditional hyperplastic polyps (HPs). Using published morphologic criteria we reviewed H&E slides of 107 polyps from 80 patients. Thirty-nine (364%) polyps met the criteria,for SPAR Within a given region, polyps in the transverse colon had the largest percentage of SPAPs (50.0%) followed by the right colon (40.9%). The majority of SPAPs (82.1%) and HPs (72.1%) showed MIB-1 staining confined to the basal third of the crypts. The majority of SPAPs (59.0%) and HPs (52.9%) showed MCM-2 staining extending into the apical third of the crypts. We do not recommend MIB-1 or MCM-2 staining to differentiate SPAPs from conventional HPs, since staining characteristics are not significantly different between the 2 groups, and frequent variable crypt staining within a given polyp is difficult to interpret.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | HYPERPLASTIC POLYPOSIS; NEOPLASIA; ADENOMAS; PATHWAY; COLON; hyperplastic polyp; serrated polyp; serrated reoplasia pathway; MIB-1; MCM-2 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Feb 2021 08:03 |
| Last Modified: | 18 Feb 2021 08:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34799 |
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