Seifarth, Christian and Mack, Matthias and Steinlicht, S and Hahn, EG and Lohmann, T (2006) Transient chemokine receptor blockade does not prevent, but may accelerate type 1 diabetes in prediabetic NOD mice. HORMONE AND METABOLIC RESEARCH, 38 (3). pp. 167-171. ISSN 0018-5043,
Full text not available from this repository. (Request a copy)Abstract
The influx of autoreactive lymphocytes into the site of an autoimmune inflammation is mediated by certain chemokines. Autoimmune insulitis in type 1 diabetes is viewed as the result of destructive Th-1-cells and their corresponding antigen-presenting cells infiltrating the pancreatic islets. Blocking the chemokine receptors that mediate a Th-1-reaction has been shown to reduce autoimmunity in other experimental autoimmune disorders. We used the NOD mouse model to investigate the potency of anti-CCR2 and anti-CCR5 antibodies to inhibit the influx of Th-1-cells into the pancreatic islets, thus preventing diabetes onset. Eleven-week-old female NOD mice were treated with 500 mu g of a monoclonal anti-CCR5 or anti-CCR2 or an isotype control anti-body every third day over two weeks. We did not observe any preventive effect in either treatment group, but accelerated diabetes onset in the anti-CCR5 treated group. The number of autoantigen-specific Th-1-cells detected in the two treated groups was not reduced, but increased in the anti-CCR5 group. Redundancy within the chemokine system may account for this lack of prevention, or the intervention may have come too late in the disease process. Furthermore, blocking Th-1 chemokine receptors in the late autoimmune process may also inhibit regulatory T-cells, thus accelerating rather than preventing the disease.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | COLLAGEN-INDUCED ARTHRITIS; CCR5 RECEPTOR; T-CELLS; PROGRESSION; EXPRESSION; INFLAMMATION; RESPONSES; IMMUNITY; autoimmune insulitis; regulatory T-cells; Th-1 cells; CCR2; CCR5; redundancy |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin I |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Feb 2021 11:18 |
| Last Modified: | 18 Feb 2021 11:18 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34859 |
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