Hau, Peter and Kunz-Schughart, Leoni A. and Ruemmele, Petra and Arslan, Fuesun and Doerfelt, Anett and Koch, Horst and Lohmeier, Annette and Bosserhoff, Anja Katrin (2006) Tenascin-C protein is induced by Transforming Growth Factor-beta 1 but does not correlate with time to tumor progression in high-grade gliomas. JOURNAL OF NEURO-ONCOLOGY, 77 (1). pp. 1-7. ISSN 0167-594X,
Full text not available from this repository. (Request a copy)Abstract
Background: Tenascin-C is an extracellular matrix protein known to correlate with prognosis in patients with glioblastoma, probably by stimulation of invasion and neoangiogenesis. Transforming Growth Factor-beta 1 (TGF-beta 1) plays an important role in the biology of high-grade gliomas, partly by regulating Invasion of these tumors into parenchyma. This study was designed to evaluate if TGF-beta 1 induces the expression and deposition of Tenascin-C in the extracellular matrix of high-grade gliomas which may be pivotal for the invasion of these tumors into healthy parenchyma. Methods: A series of 20 high-grade gliomas was stained immunohistochemically with Tenascin-C- and TGF-beta 1-specific antibodies. Expression levels of both proteins were evaluated and correlated with each other, time to progression and molecular and morphological markers of invasion. A quantitative PCR assay was performed evaluating the induction of Tenascin-C mRNA by treatment with TGF-beta 1 in vitro. Results: Tenascin-C was expressed in 18 of 19 (95%) evaluable tumors, whereas 14 of 20 tumors (70%) expressed TGF-beta 1 in a significant percentage of cells. Treatment with TGF-beta 1 did induce the expression of Tenascin-C at the mRNA and protein level in vitro. The expression of Tenascin-C and TGF-beta 1 did neighter statistically correlate with each other nor with time to progression. Conclusion: In our series, Tenascin-C and TGF-beta 1 were expressed in the vast majority of high-grade gliomas. We could not detect a correlation of one of the proteins with time to progression. Nevertheless, we describe induction of Tenascin-C by TGF-beta 1, possibly providing a mechanism for the invasion of high-grade gliomas into healthy parenchyma.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GROWTH-FACTOR-BETA; EXTRACELLULAR-MATRIX; CELL INVASION; BRAIN-TUMORS; EXPRESSION; ANGIOGENESIS; MIGRATION; RELEVANCE; SURVIVAL; ADHESION; anaplastic astrocytoma; glioblastoma; high-grade gliomas; induction; prognosis; Tenascin-C; TGF-beta 1 |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Feb 2021 13:38 |
| Last Modified: | 18 Feb 2021 13:38 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34875 |
Actions (login required)
 |
View Item |
