Rieger, D and Shafer, OT and Tomioka, K and Helfrich-Foerster, Charlotte (2006) Functional analysis of circadian pacemaker neurons in Drosophila melanogaster. JOURNAL OF NEUROSCIENCE, 26 (9). pp. 2531-2543. ISSN 0270-6474,
Full text not available from this repository. (Request a copy)Abstract
The molecular mechanisms of circadian rhythms are well known, but how multiple clocks within one organism generate a structured rhythmic output remains a mystery. Many animals show bimodal activity rhythms with morning ( M) and evening ( E) activity bouts. One long-standing model assumes that two mutually coupled oscillators underlie these bouts and show different sensitivities to light. Three groups of lateral neurons (LN) and three groups of dorsal neurons govern behavioral rhythmicity of Drosophila. Recent data suggest that two groups of the LN ( the ventral subset of the small LN cells and the dorsal subset of LN cells) are plausible candidates for the M and E oscillator, respectively. We provide evidence that these neuronal groups respond differently to light and can be completely desynchronized from one another by constant light, leading to two activity components that free-run with different periods. As expected, a long-period component started from the E activity bout. However, a short-period component originated not exclusively from the morning peak but more prominently from the evening peak. This reveals an interesting deviation from the original Pittendrigh and Daan ( 1976) model and suggests that a subgroup of the ventral subset of the small LN acts as "main" oscillator controlling M and E activity bouts in Drosophila.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | LOCOMOTOR-ACTIVITY RHYTHM; RAT SUPRACHIASMATIC NUCLEUS; CLOCK-GENE; INDIVIDUAL-DIFFERENCES; ARVICANTHIS-NILOTICUS; DISCONNECTED MUTANTS; BEHAVIORAL RHYTHMS; NOCTURNAL RODENTS; ACTIVITY PATTERN; LATERAL NEURONS; period; timeless; dual oscillators; internal desynchronization; constant light; cryptochrome |
| Subjects: | 500 Science > 590 Zoological sciences |
| Divisions: | Biology, Preclinical Medicine > Institut für Zoologie > Alumni or Retired > Organisation der inneren Uhr auf neuronaler Ebene (Prof. Dr. Charlotte Förster) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 18 Feb 2021 13:40 |
| Last Modified: | 18 Feb 2021 13:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34876 |
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