Meimarakis, Georgios and Winter, Hauke and Assmann, Ilka and Kopp, Reinhard and Lehn, Norbert and Kist, Manfred and Stolte, Manfred and Jauch, Karl-Walter and Hatz, Rudolf A. (2006) Helicobacter pylori as a prognostic indicator after curative resection of gastric carcinoma: a prospective study. LANCET ONCOLOGY, 7 (3). pp. 211-222. ISSN 1470-2045,
Full text not available from this repository. (Request a copy)Abstract
Background The effect of Helicobaaer-pylori status on survival after curative resection for gastric adenocarcinoma is unknown. We aimed to follow-up patients who were positive or negative for infection with H pylori who had curative (ie, R0) resection for gastric adenocarcinoma to assess differences in relapse-free survival and overall survival. Methods Before surgery, we assessed the H pylori status of 166 patients who had R0 resection for gastric adenocarcinoma between 1992 and 2002 with bacterial culture, histological analyses (ie, staining with haematoxylin and eosin and with Warthin-Starry), and serological analyses. Findings At a median follow-up of 53(.)0 months (range 1-146), relapse-free survival was 56(.)7 months (95% Cl 4.7-108(.)7) and overall survival was 61(.)9 months (13(.)0-110(.)9) in patients positive for H pylori, compared with 19(.)2 months (12(.)7-25(.)6) and 19.2 months (7(.)1-31(.)3), respectively, in patients negative for H pylori (p=0(.)0009 for difference in relapse-free survival between groups, and p=0(.)0017 for difference in overall survival between groups). In multivariate analyses, H pylori was an independent prognostic factor for relapse-free survival (hazard ratio 2(.)16 [95% CI 1(.)33-3(.)49]) and overall survival (2(.)00 [1(.)22-3(.)27]). Depth of tumour invasion (2(.)60 [1(.)66-4(.)08]), lymph-node metastasis (2-11 [1(.)25-3(.)57]), and patient age 67(.)5 years or older (1(.)75 [1(.)11-2(.)75]) were also independent prognostic factors for overall survival. Interpretation Tumour-specific immune responses might be downregulated in patients who are negative for H pylori, and these patients should be followed up carefully because of a poor outlook.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | DISTINCT CLINICOPATHOLOGICAL FEATURES; SERUM CARCINOEMBRYONIC ANTIGEN; LYMPH-NODE DISSECTION; MICROSATELLITE INSTABILITY; T-CELLS; INTESTINAL METAPLASIA; CANCER; EXPRESSION; LIGAND; ADENOCARCINOMAS; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2021 06:36 |
| Last Modified: | 22 Feb 2021 06:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34881 |
Actions (login required)
 |
View Item |
