Hoffmann, Ute and Banas, Bernhard and Kruger, Bernd and Pietrzyk, Miriam and Obed, Aiman and Segerer, Stephan and Kammerl, Martin and Ruemmele, Petra and Riegger, Guenter A. J. and Kramer, Bernhard K. (2006) Expression of cyclooxygenase-1 and cyclooxygenase-2 in human renal allograft rejection - a prospective study. TRANSPLANT INTERNATIONAL, 19 (3). pp. 203-212. ISSN 0934-0874, 1432-2277
Full text not available from this repository. (Request a copy)Abstract
Cyclooxygenases (COX) are known to be involved in inflammatory kidney diseases. However, there are no data available about the expression of COX-1 and only preliminary reports about the expression of COX-2 in biopsies of patients undergoing acute renal allograft rejection. We conducted this prospective study to analyze the expression, distribution, and cellular localization of COX-1 and -2 and thus to elucidate the role of COX in human kidney transplantation. One hundred forty-four biopsies were included from patients without rejection and unaltered morphology (n = 60), with acute interstitial rejection (n = 7), with acute vascular rejection (n = 21), with chronic allograft nephropathy (n = 16), without rejection but with various other lesions (n = 40). COX-1 and -2 expression was localized in each biopsy by immunohistochemistry. We found a highly significant up-regulation of COX-1 in vessels and in infiltrating interstitial cells of patients with acute allograft rejection compared with biopsies with well-preserved tissue. Also, COX-2 expression was significantly elevated in infiltrating interstitial cells of biopsies with acute rejection. This is the first prospective study demonstrating a significant induction of both COX-1 and -2 in human allograft biopsies with acute rejection after renal transplantation.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | MACULA DENSA; PROSTAGLANDIN E-2; CYCLOSPORINE-A; UP-REGULATION; INDUCIBLE CYCLOOXYGENASE; NITRIC-OXIDE; HUMAN KIDNEY; RAT-KIDNEY; T-CELLS; INHIBITION; cyclooxygenases-1; cyclooxygenases-2; human renal allograft rejection; immunohistochemistry |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Chirurgie Medicine > Lehrstuhl für Innere Medizin II Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2021 09:34 |
| Last Modified: | 22 Feb 2021 09:34 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34923 |
Actions (login required)
 |
View Item |
