Knoell, Antje and Hartmann, Arndt and Hamoshi, Harald and Weislmaier, Karin and Jilg, Wolfgang (2006) Serological pattern "anti-HBc alone": Characterization of 552 individuals and clinical significance. WORLD JOURNAL OF GASTROENTEROLOGY, 12 (8). pp. 1255-1260. ISSN 1007-9327, 2219-2840
Full text not available from this repository. (Request a copy)Abstract
AIM: To investigate the prevalence and clinical significance of "anti-HBc alone" in an unselected population of patients and employees of a university hospital in southern Germany. METHODS: All individuals with the pattern "anti-HBc alone" were registered over a time span of 82 mo. HBV-DNA was measured in serum and liver samples, and clinical charts were reviewed. RESULTS: Five hundred and fifty two individuals were "anti-HBc alone" (of 3004 anti-HBc positive individuals; 18.4%), and this pattern affected males (20.5%) more often than females (15.3%; P < 0.001). HBV-DNA was detected in serum of 44 of 545 "anti-HBc alone" individuals (8.1%), and in paraffin embedded liver tissue in 16 of 39 patients tested (41.0%). There was no association between the detection of HBV genomes and the presence of biochemical, ultrasonic or histological signs of liver damage. Thirty-eight "anti-HBc alone" patients with cirrhosis or primary liver carcinoma had at least one additional risk factor. HCV-coinfection was present in 20.4% of all individuals with "anti-HBc alone" and was the only factor associated with a worse clinical outcome. CONCLUSION: In an HBV low prevalence area, no evidence is found that HBV alone causes severe liver damage in individuals with "anti-HBc alone". Recommendations for the management of these individuals are given. (c) 2006 The WJG Press. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | B SURFACE-ANTIGEN; CHRONIC HEPATITIS-B; VIRUS-INFECTION; CORE ANTIGEN; DNA; FREQUENCY; TRANSPLANTATION; CHEMOTHERAPY; REACTIVATION; POLYMERASE; HBV markers; HBV serology; hepatitis B virus; hepatocellular carcinoma; occult HBV infection |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene Medicine > Lehrstuhl für Pathologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2021 10:03 |
| Last Modified: | 22 Feb 2021 10:03 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34931 |
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