Madisch, Ahmed and Miehlke, S. and Neuber, F. and Morgner, A. and Kuhlisch, E. and Rappel, S. and Lehn, N. and Bayerdorffer, E. and Seitz, G. and Stolte, M. (2006) Healing of lymphocytic gastritis after Helicobacter pylori eradication therapy - a randomized, double-blind, placebo-controlled multicentre trial. ALIMENTARY PHARMACOLOGY & THERAPEUTICS, 23 (4). pp. 473-479. ISSN 0269-2813,
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Background:An association between Helicobacter pylori infection and lymphocytic gastritis has been postulated. Aim:To assess the long-term effect of H. pylori eradication therapy on lymphocytic gastritis in a double-blind, placebo-controlled, multicentre trial. Methods:Patients with lymphocytic gastritis were randomized to receive either 1-week triple therapy for eradication of H. pylori or omeprazole plus placebo. Endoscopy and histology was performed at baseline and after 3 and 12 months. Patients of the omeprazole/placebo group with persistent lymphocytic gastritis after 12 months received crossover open-label triple therapy. Results:Fifty-one patients were randomized. Intention-to-treat analysis revealed a trend to a higher healing rate of lymphocytic gastritis 3 months after triple therapy compared with omeprazole/placebo (83.3% vs. 57.7%, 95% CI for RR: 0.8-2.8, P = 0.06). After 12 months, the healing rate of lymphocytic gastritis was significantly higher after triple therapy compared with omeprazole/placebo (intention-to-treat 95.8% vs. 53.8%, 95% CI for RR: 1.1-3.5, P = 0.01). All patients (n = 5) who received crossover triple therapy, showed healing of lymphocytic gastritis after further 12 months. Conclusions:Our study demonstrates that 1-week triple therapy aiming at eradication of H. pylori leads to a complete and long-lasting resolution of lymphocytic gastritis in the majority of patients.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | GASTROINTESTINAL PROTEIN LOSS; INFECTION; DISEASE; OMEPRAZOLE; ULCER; GASTROPATHY; RESOLUTION; CURE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 22 Feb 2021 10:36 |
| Last Modified: | 22 Feb 2021 10:36 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34938 |
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