Klucken, Jochen and Ingelsson, Martin and Shin, Young-Ah and Irizarry, Michael C. and Hedley-Whyte, E. T. and Frosch, Matthew P. and Growdon, John H. and McLean, Pamela J. and Hyman, Bradley T. (2006) Clinical and biochemical correlates of insoluble alpha-synuclein in dementia with Lewy bodies. ACTA NEUROPATHOLOGICA, 111 (2). pp. 101-108. ISSN 0001-6322, 1432-0533
Full text not available from this repository. (Request a copy)Abstract
alpha-Synuclein is a major constituent of Lewy bodies, the fibrillar aggregates that form within neurons in Parkinson's disease and dementia with Lewy bodies (DLB). Recent biochemical data show that alpha-synuclein accumulates in Parkinson's disease in a detergent insoluble form. We now examine the relationship between detergent insoluble alpha-synuclein and the presence of Lewy bodies, clinical measures of dementia and biochemical parameters in a series of individuals with DLB. We found that Triton X-100 insoluble alpha-synuclein enriched nearly twofold in the temporal cortex of patients with DLB compared to age-matched controls. By contrast the total amount of alpha-synuclein protein was unchanged. Surprisingly, the degree of Triton X-100 insoluble alpha-synuclein did not correlate with either the duration of illness or the number of Lewy bodies counted using stereological methods from an adjacent block of tissue. However, the Triton X-100 soluble fraction of alpha-synuclein did correlate strongly with the expression of several heat shock proteins (HSPs) in DLB but not control cases, suggesting a coordinated HSP response in DLB neocortex.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PARKINSONS-DISEASE; BODY DISEASE; ALZHEIMER-DISEASE; CORTEX; ACCUMULATION; SUPPRESSION; MUTATION; BRAIN; NEUROPATHOLOGY; AGGREGATION; alpha-synuclein; Lewy body dementia; heat shock proteins |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Neurologie |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 23 Feb 2021 12:24 |
| Last Modified: | 23 Feb 2021 12:24 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34950 |
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