Pihusch, Markus and Pihusch, Rudolf and Fraunberger, Peter and Pihusch, Verena and Andreesen, Reinhard and Kolb, Hans-Jochem and Holler, Ernst (2006) Evaluation of C-reactive protein, interleukin-6, and procalcitonin levels in allogeneic hematopoietic stem cell recipients. EUROPEAN JOURNAL OF HAEMATOLOGY, 76 (2). pp. 93-101. ISSN 0902-4441,
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Background: Prompt detection of transplant-related complications (TRC) as infections, acute graft-versus-host disease (aGVHD), microangiopathic hemolytic anemia, or veno-occlusive disease following allogeneic hematopoietic stem cell transplantation (HSCT) is essential. Patients and methods: We conducted a prospective trial on clinical significance of C-reactive protein (CRP), interleukin-6 (IL-6) and procalcitonin (PCT) serum levels in TRC. A total of 350 stem cell recipients were admitted. CRP, IL-6 and PCT were analyzed prior to conditioning and weekly until 8 wk after HSCT. TRC were recorded weekly throughout the study. Results: CRP (4.4 mg/dL vs. 12.8 mg/dL; P < 0.001), IL-6 (93 ng/mL vs. 1.138 ng/mL; P < 0.001) and PCT (0.8 ng/dL vs. 5.7 ng/dL; P < 0.001) were increased in infectious complications. Only PCT differentiated between infection and other TRC. Exclusive aGVHD did not increase CRP (4.4 mg/dL vs. 5.7 mg/dL; n.s.), IL-6 (93 ng/mL vs. 153 ng/mL; n.s.) and PCT (0.8 ng/dL vs. 0.8 ng/dL n.s.). CRP (6.1 mg/dL vs. 3.1 ing/dL; P < 0.001) and IL-6 (295 ng/mL vs. 122 ng/mL; P = 0.001) decreased during steroid therapy, but not PCT (2.3 ng/dL vs. 2.0 ng/dL; n.s.). Conclusion: Our study confirmed CRP, IL-6 and serum levels as helpful markers for TRC. PCT can differentiate infection from GVHD despite steroid therapy. Further trials are needed focusing on the identification of patients who benefit from early risk stratification.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BONE-MARROW-TRANSPLANTATION; VERSUS-HOST-DISEASE; SERUM LEVELS; VENOOCCLUSIVE DISEASE; CYTOKINE LEVELS; MAJOR COMPLICATIONS; IL-6 LEVELS; CHILDREN; SEPSIS; GRAFT; hematopoietic stem cell transplantation; C-reactive protein; interleukin-6; procalcitonin |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Feb 2021 06:40 |
| Last Modified: | 24 Feb 2021 06:40 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34977 |
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