Mahboobi, Siavosh and Eichhorn, Emerich and Popp, Alfred and Sellmer, Andreas and Elz, Sigurd and Moellmann, Ute (2006) 3-bromo-4-(1H-3-indolyl)-2,5-dihydro-1H-2,5-pyrroledione derivatives as new lead compounds for antibacterially active substances. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 41 (2). pp. 176-191. ISSN 0223-5234,
Full text not available from this repository. (Request a copy)Abstract
A number of new compounds containing 3-bromo-2,5-dihydro-1H-2,5-pyrroledione and indole substructures were found to have antibacterial activity against resistant strains of Staphylococcus aureus, Mycobacterium smegmatis and some other Gram positive bacteria. The investigated compounds exhibit minimal inhibition concentrations (MIC's) lower than those of ciprofloxacin, vancomycin and doxycycline resp. A different spectrum of activity, suggests a mechanism of action different to vancomycin and doxycycline. This might be important in circumventing existing resistance mechanisms. Here we report about the synthesis and on the antibacterial activity in a structure activity relationship study. (c) 2005 Elsevier SAS. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | PERFORMANCE LIQUID-CHROMATOGRAPHY; PROTEIN-KINASE-C; PARTITION-COEFFICIENTS; SUBSTITUTED INDOLES; INHIBITORS; REAGENTS; SAR-study; antibacterial; indole derivatives; resistant Staphylococcus aureus; Mycobacterium smegmatis |
| Subjects: | 600 Technology > 615 Pharmacy |
| Divisions: | Chemistry and Pharmacy > Institute of Pharmacy > Pharmaceutical/Medicinal Chemistry I (Prof. Elz) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Feb 2021 06:43 |
| Last Modified: | 24 Feb 2021 06:43 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34978 |
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