Loew, Thomas H. and Nickel, Marius K. and Muehlbacher, Moritz and Kaplan, Patrick and Nickel, Cerstin and Kettler, Christian and Fartacek, Reinhold and Lahmann, Claas and Buschmann, Wiebke and Tritt, Karin and Bachler, Egon and Mitterlehner, Ferdinand and Gil, Francisco Pedrosa and Leiberich, Peter and Rother, Wolfhardt K. and Egger, Christoph (2006) Topiramate treatment for women with borderline personality disorder - A double-blind, placebo-controlled study. JOURNAL OF CLINICAL PSYCHOPHARMACOLOGY, 26 (1). pp. 61-66. ISSN 0271-0749, 1533-712X
Full text not available from this repository. (Request a copy)Abstract
Borderline personality disorder is a common and severe psychiatric illness. The goal of this study was to determine whether topiramate can influence patients' borderline psychopathology, health-related quality of life, and interpersonal problems. Women meeting the Diagnostic and Statistical Manual of Mental Disorders. Fourth Edition Structured Clinical Interview II criteria for borderline personality disorder were randomly assigned in a 1: 1 ratio to topiramate titrated from 25 to 200 mg/d (n = 28) or placebo (n = 28) for 10 weeks. Primary outcome measures were changes on the Symptom-Checklist, on the SF-36 Health Survey, an on the Inventory of Interpersonal Problems. Body weight and additional side effects were assessed weekly. According to the intent-to-treat principle, significant changes (all P < 0.001) on the somatization, interpersonal sensitivity, anxiety, hostility, phobic anxiety, and Global Severity Index scales of the Symptom Checklist were observed in the topiramate-treated subjects after 10 weeks (no significant changes on the obsessive-compulsive, depression, paranoid ideation, and psychoticism scales). In the SF-36 Health Survey, significant differences were observed on all 8 scales (all P < 0.01 or P < 0.001). In the Inventory of Interpersonal Problems, significant differences (all P < 0.001) were found in the scales for overly autocratic, overly competitive, overly introverted, and overly expressive (no significant differences in the scales for overly cold, overly subassertive/subservient, overly exploitable/compliant, and overly nurturant/friendly). Weight loss was additionally observed (P < 0.001). Topiramate appears to be a safe and effective agent in the treatment in women with borderline personality disorder. Additional weight loss can be expected.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | BIPOLAR-II-DISORDER; DIVALPROEX SODIUM; AGGRESSION; SYMPTOMS; COMORBIDITY; SAMPLE; SERIES; TRIAL; ANGER; GABA; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Abteilung für Psychosomatische Medizin |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Feb 2021 09:09 |
| Last Modified: | 24 Feb 2021 09:09 |
| URI: | https://pred.uni-regensburg.de/id/eprint/34997 |
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