Guenther, Matthias and Neuhaus, Ruth and Bauer, Tanja and Jilg, Wolfgang and Holtz, Jan Arne and Bienzle, Ulrich (2006) Immunization with an adjuvant hepatitis B vaccine in liver transplant recipients: Antibody decline and booster vaccination with conventional vaccine. LIVER TRANSPLANTATION, 12 (2). pp. 316-319. ISSN 1527-6465, 1527-6473
Full text not available from this repository. (Request a copy)Abstract
Patients after orthotopic liver transplantation (OLT) due to hepatitis B virus (HBV)-related disease are at risk of endogenous hepatitis B reinfection and may receive life long prophylaxis with hepatitis B hyperimmunoglobulin (HBIG). In a previous study 16 of 20 OLT patients were immunized successfully with an adjuvant hepatitis B vaccine. To maintain protective antibody levels under immunosuppressive therapy, 11 of these patients were revaccinated with a double dosed conventional hepatitis B vaccine. Median interval between last vaccination and booster was 24 months (range 22-31 months). Antibody titres against hepatitis B surface antigen (anti-HBs) were monitored at the day of booster vaccination (day 0), at day 7 and day 28. At day 0, all vaccinees but one had anti-HBs titres greater than 500 IU/L (median 1,925 IU/L, range 196-7,612 IU/L). Maximum antibody titres after previous vaccination declined by a median of 82% (range 47-96%). After booster vaccination the anti-HBs titre increased significantly by a median factor of 2.42 (P < 0.05). In conclusion, the majority of liver transplant recipients who previously had responded to adjuvant hepatitis B vaccine exhibited sufficient immunocompetence to produce a substantial antibody response after booster immunization with a conventional vaccine.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | SURFACE-ANTIGEN; PROPHYLAXIS; MEMORY; RECURRENCE; LAMIVUDINE; CIRRHOSIS; FAILURE; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Medizinische Mikrobiologie und Hygiene |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 24 Feb 2021 09:41 |
| Last Modified: | 24 Feb 2021 09:41 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35007 |
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