Weber, D. and Oefner, P. J. and Dettmer, K. and Hiergeist, A. and Koestler, J. and Gessner, A. and Weber, M. and Staemmler, F. and Hahn, J. and Wolff, D. and Herr, W. and Holler, E. (2016) Rifaximin preserves intestinal microbiota balance in patients undergoing allogeneic stem cell transplantation. BONE MARROW TRANSPLANTATION, 51 (8). pp. 1087-1092. ISSN 0268-3369, 1476-5365
Full text not available from this repository. (Request a copy)Abstract
Intestinal dysbiosis has been associated with acute gastrointestinal GvHD and poor outcome following allogeneic stem cell transplantation (ASCT). To assess the effect of a switch in 2012 from ciprofloxacin/metronidazole to rifaximin for gut decontamination on intestinal microbiota composition and ASCT outcome, we retrospectively analyzed 394 patients receiving ASCT from September 2008 through June 2015. In 131 and 90 patients, respectively, urinary 3-indoxyl sulfate levels and intestinal enterococcal load were measured before conditioning and weekly within the first 28 days after ASCT. The use of rifaximin correlated with lower enterococcal positivity (6.9 vs 21.9%, P = 0.05) and higher urinary 3-indoxyl sulfate concentrations (10.5 vs 4.6 mu moL/mmoL crea, P < 0.001) after ASCT. Patients on rifaximin showed lower 1-year transplant-related mortality (P = 0.04) and higher overall survival (P = 0.008). Treatment of infectious complications with systemic antibiotics did not abrogate the beneficial effects of rifaximin on intestinal microbiota composition in the early course of ASCT and outcome. The data underscore the importance of maintaining a diverse population of symbiotic and mutualistic bacteria in the gut on ASCT outcome.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | VERSUS-HOST-DISEASE; BONE-MARROW-TRANSPLANTATION; INFLAMMATORY-BOWEL-DISEASE; CROHNS-DISEASE; PHARMACOLOGY; DIVERSITY; TRIAL; |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Innere Medizin III (Hämatologie und Internistische Onkologie) |
| Depositing User: | Dr. Gernot Deinzer |
| Date Deposited: | 29 Mar 2019 12:14 |
| Last Modified: | 29 Mar 2019 12:14 |
| URI: | https://pred.uni-regensburg.de/id/eprint/3501 |
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