Schmitz, Gerd and Langmann, Thomas (2006) Pharmacogenomics of cholesterol-lowering therapy. VASCULAR PHARMACOLOGY, 44 (2). pp. 75-89. ISSN 1537-1891, 1879-3649
Full text not available from this repository. (Request a copy)Abstract
The prevention of cardiovascular disease is critically dependent oil lipid-lowering therapy, including 3 -hydroxymethyl-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors (statins), cholesterol absorption inhibitors, bile acid resins, fibrates, and nicotinic acid. Although these drugs are generally well tolerated, severe adverse effects can occur in a minority of patients. Furthermore, a subset of patients does not respond to cholesterol-lowering therapy with a reduction in coronary heart disease progression. Significant progress has been made in the identification of common DNA sequence variations in genes influencing the pharmacokinetics and pharmacodynamics of statins and in disease-modifying genes relevant for coronary heart disease (CHD). Among the most promising candidate genes for pharmacogenomic analysis of statin therapy are HMG-CoA reductase as a direct target gene and other genes modulating lipid and lipoprotein homeostasis. Based on data from pharmacogenetic trials, a combined analysis of multiple genetic variants in several genes is more likely to give significant results than single gene studies in small cohorts. In the future, pharmacogenomic testing may allow risk stratification of patients to avoid serious side effects and enable clinicians to select lipid-lowering drugs with the highest efficacy resulting in the best response to therapy. (c) 2005 Elsevier Inc. All rights reserved.
| Item Type: | Article |
|---|---|
| Uncontrolled Keywords: | CORONARY-HEART-DISEASE; COA REDUCTASE INHIBITORS; DENSITY-LIPOPROTEIN CHOLESTEROL; TRANSFER PROTEIN GENE; SCANDINAVIAN SIMVASTATIN SURVIVAL; PLASMA PRAVASTATIN CONCENTRATIONS; PROLIFERATOR-ACTIVATED RECEPTORS; APOLIPOPROTEIN-E POLYMORPHISM; RANDOMIZED CONTROLLED-TRIALS; STATIN-ASSOCIATED MYOPATHY; HMG-CoA reductase inhibitors; pharmacogenomics; pharmacogenetics; polymorphisms |
| Subjects: | 600 Technology > 610 Medical sciences Medicine |
| Divisions: | Medicine > Lehrstuhl für Klinische Chemie und Laboratoriumsmedizin |
| Depositing User: | Petra Gürster |
| Date Deposited: | 10 Feb 2021 11:31 |
| Last Modified: | 10 Feb 2021 11:31 |
| URI: | https://pred.uni-regensburg.de/id/eprint/35024 |
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